Pavlides C, Kimura A, Magariños A M, McEwen B S
Rockefeller University, New York, NY 10021.
Neuroreport. 1994 Dec 20;5(18):2673-7. doi: 10.1097/00001756-199412000-00067.
The effects of Type I adrenal steroid receptors in prolonging synaptic plasticity in the dentate gyrus of freely behaving rats was investigated. Rats were implanted with chronic, bilateral stimulating and recording electrodes in the perforant pathway and dentate gyrus, respectively, and adrenalectomized (ADX). After a 2-3 day recovery period, baseline recordings of field potentials were made followed by administration of aldosterone or vehicle. One hour later, high frequency stimulation (HFS; chosen to produce comparable long-term potentiation (LTP) in the aldosterone-treated and control groups) was applied unilaterally and recording was continued for 1 h and again performed at 3, 24 and 48 h. LTP in ADX controls decayed significantly within 3 h, and returned to baseline levels at 24 h. In contrast, the aldosterone-treated animals showed enhanced LTP at 3, 24 and 48 h. These findings demonstrate that aldosterone both enhances and prolongs hippocampal plasticity.
研究了I型肾上腺类固醇受体对自由活动大鼠齿状回突触可塑性延长的影响。分别在大鼠的穿通通路和齿状回慢性植入双侧刺激和记录电极，并进行肾上腺切除（ADX）。在2-3天的恢复期后，记录场电位的基线，然后给予醛固酮或赋形剂。1小时后，单侧施加高频刺激（HFS；选择在醛固酮处理组和对照组中产生相当的长期增强（LTP）），并持续记录1小时，在3、24和48小时再次进行记录。ADX对照组中的LTP在3小时内显著衰减，并在24小时恢复到基线水平。相比之下，接受醛固酮治疗的动物在3、24和48小时显示出增强的LTP。这些发现表明醛固酮既能增强又能延长海马可塑性。
