他莫昔芬在乳腺癌治疗及化学预防中的应用
Tamoxifen in the treatment and chemoprevention of breast cancer.
作者信息
Boothe V A, Pommier R F, Vetto J T
出版信息
Cancer Pract. 1994 Sep-Oct;2(5):335-42.
PMID:7697071
Abstract
Synthesized in 1966 and initially tested as a potential contraceptive, the nonsteroidal antiestrogen tamoxifen was subsequently found to have therapeutic benefits in the therapy of breast cancer. Today, tamoxifen is widely used in the treatment of this disease both in an adjuvant setting and for metastatic tumor. This article explores the history, pharmacology, and adverse effects of tamoxifen and summarizes the clinical evidence for its current indications and potential future use as a chemopreventative agent.
摘要
非甾体类抗雌激素他莫昔芬于1966年合成，最初作为一种潜在的避孕药进行测试，随后发现它在乳腺癌治疗中具有治疗益处。如今，他莫昔芬广泛用于这种疾病的辅助治疗和转移性肿瘤的治疗。本文探讨了他莫昔芬的历史、药理学和不良反应，并总结了其当前适应症的临床证据以及作为化学预防剂潜在的未来用途。
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