长效促黄体生成素释放激素（LH-RH）类似物在女性不孕症治疗中的应用
Long-acting luteinizing homone-releasing hormone (LH-RH) analogs in the treatment of female infertility.
作者信息
Forsbach G, Ayala A, Zarate A, Canales E S, Soria J, Schally A V, Kastin A J, Coy D H, Coy E J
出版信息
Arch Invest Med (Mex). 1976;7(1):43-8.
Induction of ovulation in 20 infertile women was attempted by the use of two synthetic analogs of LH-RH, D-ALA6-Des-Gly10-ethylamide and D-Leu6-Des-Gly10-ethylamide. Ovulation was obtained in five out of the 16 in whom D-Leu6-Des-Gly10-LH-RH ethylamide was administered intramuscularly. Two of the five women received the LH-RH analog additioned of polysaturated gelatines as carrier medium. None of these women got pregnant. It is concluded that better therapeutic results might be expected when a suitable LH-RH vehicle allowing a gradual release of LH-RH analog is obtained.
尝试使用两种促黄体生成素释放激素（LH-RH）的合成类似物，即D-丙氨酸6-去甘氨酸10-乙酰胺和D-亮氨酸6-去甘氨酸10-乙酰胺，对20名不孕妇女进行排卵诱导。在16名肌肉注射D-亮氨酸6-去甘氨酸10-LH-RH乙酰胺的患者中，有5人排卵。这5名女性中有2人接受了添加多饱和明胶作为载体介质的LH-RH类似物。这些女性均未怀孕。得出的结论是，当获得一种能使LH-RH类似物逐渐释放的合适LH-RH载体时，可能会预期有更好的治疗效果。
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