The action of ANP, BNP and related peptides on motivated behavior in rats.

This review summarizes the action of atrial natriuretic (ANP) and some related compounds such as BNP, CNP and fragments on the central nervous system, based mainly on the results obtained in the author's laboratory. The aim of the investigations was to assess the physiological significance of the natriuretic peptide family in the brain by administering the peptides into the lateral brain ventricle. Effects were studied on motivated behavior, including active and passive avoidance learning, food-reinforced conditioning, open-field activity, electroshock-induced amnesia, development of morphine tolerance and dependence, and picrotoxin-kindled seizure syndrome. Antisera against ANP were used in order to follow the specificity of the resulting action. The role of neurotransmitters in the mediation of peptide action was elucidated by treating the animals with receptor blockers before peptide administration.