Owens M L, Wilson S E, Saltzman R, Gordon H E
Arch Surg. 1976 Apr;111(4):467-71. doi: 10.1001/archsurg.1976.01360220163027.
In a ten-year study involving 109 renal transplant patients, 37 (34%) developed gastrointestinal complications. The immediate mortality from these complications was 27%. Three of four patients with erosive gastritis died. Five deaths occurred among 17 patients who developed ulcers after transplantation. Emergency surgery for ulcers resulted in two deaths. Patients with peptic ulcer disease, esophagitis, or bleeding before transplantation were much more likely to develop recurrences that patients not so affected. Peptic ulcer occurred notably more often in recipients whose kidneys came from cadavers than from related donors. Experience with gastrointestinal bleeding or its absence during a first transplant is a useful predictor of the results after a second transplant. The high recurrence rate and high mortality suggest that patients with ulcer disease demonstrated before kidney transplantation should either undergo elective surgery for ulcer disease or not be accepted for transplantation. Patients in whom ulcer disease develops after a kidney transplant shoud undergo early elective surgery.
在一项涉及109例肾移植患者的为期十年的研究中，37例（34%）出现了胃肠道并发症。这些并发症导致的直接死亡率为27%。4例糜烂性胃炎患者中有3例死亡。17例移植后发生溃疡的患者中有5例死亡。溃疡的急诊手术导致2例死亡。移植前患有消化性溃疡病、食管炎或出血的患者比未受影响的患者更容易复发。消化性溃疡在接受尸体肾移植的受者中比接受亲属供肾移植的受者中更为常见。首次移植时有无胃肠道出血的情况是第二次移植结果的一个有用预测指标。高复发率和高死亡率表明，肾移植前已证实患有溃疡病的患者应接受溃疡病择期手术，否则不应接受移植。肾移植后发生溃疡病的患者应尽早接受择期手术。
