细胞因子诱导小鼠前体CD8⁺ T细胞分化为分泌Th1或Th2细胞因子的细胞毒性CD8⁺ T细胞。
Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines.
作者信息
Sad S, Marcotte R, Mosmann T R
机构信息
Department of Immunology, University of Alberta, Edmonton, Canada.
出版信息
Immunity. 1995 Mar;2(3):271-9. doi: 10.1016/1074-7613(95)90051-9.
Alloantigen-stimulated CD8+ mouse spleen cells, either spontaneously or in the presence of IL-12 or IFN gamma plus anti-IL-4, differentiate into CD8+ T cells secreting a Th1-like cytokine pattern (IL-2 and IFN gamma). IL-4 induced differentiation into CD8+ T cells secreting Th2 cytokines (IL-4, IL-5, IL-6, and IL-10), whereas anti-IFN gamma suppressed the development of CD8+ cells secreting IFN gamma. Clones of IL-4- or IFN gamma-producing CD8+ T cells were relatively stable, as IL-4 or IFN gamma did not cause interconversion of committed CD8+ T cells. Both CD8+ subsets were cytotoxic, failed to provide cognate help for B cell antibody production, and remained CD4-, CD8 alpha+ CD8 beta+. We propose the names TC1 and TC2 for cytotoxic CD8+ T cells secreting Th1-like and Th2-like cytokines, respectively.
同种异体抗原刺激的CD8⁺小鼠脾细胞，无论是自发地，还是在白细胞介素-12（IL-12）或干扰素γ（IFNγ）加抗白细胞介素-4的存在下，都会分化为分泌Th1样细胞因子模式（IL-2和IFNγ）的CD8⁺T细胞。白细胞介素-4（IL-4）诱导分化为分泌Th2细胞因子（IL-4、IL-5、IL-6和IL-10）的CD8⁺T细胞，而抗干扰素γ抑制分泌干扰素γ的CD8⁺细胞的发育。产生白细胞介素-4或干扰素γ的CD8⁺T细胞克隆相对稳定，因为白细胞介素-4或干扰素γ不会导致已分化的CD8⁺T细胞相互转化。两个CD8⁺亚群均具有细胞毒性，无法为B细胞抗体产生提供同源辅助，并且仍然是CD4⁻、CD8α⁺CD8β⁺。我们分别将分泌Th1样和Th2样细胞因子的细胞毒性CD8⁺T细胞命名为TC1和TC2。
Zotero 插件