Ning Weisen, Yan Sheng, Song Yongyao, Xu Hanning, Zhang Jinling, Wang Xiaomei
School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Department of Oncology, Wuhan Fourth Hospital, Wuhan Orthopedic Hospital, Wuhan, Hubei, China.
Front Immunol. 2025 Jan 7;15:1504124. doi: 10.3389/fimmu.2024.1504124. eCollection 2024.
Virus-like particles (VLPs), as a unique form of nanocarrier, predominantly encompass hollow protein shells that exhibit analogous morphology and structure to naturally occurring viruses, yet devoid of genetic material. VLPs are considered safe, easily modifiable, and stable, making them suitable for preparation in various expression systems. They serve as precise biological instruments with broad applications in the field of medical biology. Leveraging their unique structural attributes and facile modification capabilities, VLPs can serve as an effective platform for the delivery of tumor antigens, thereby stimulating the immune system and facilitating the eradication of tumor cells.
病毒样颗粒（VLPs）作为一种独特形式的纳米载体，主要由中空蛋白壳组成，这些蛋白壳在形态和结构上与天然存在的病毒相似，但不含遗传物质。VLPs被认为是安全的、易于修饰的和稳定的，这使得它们适合在各种表达系统中制备。它们是精确的生物工具，在医学生物学领域有着广泛的应用。利用其独特的结构特性和易于修饰的能力，VLPs可以作为递送肿瘤抗原的有效平台，从而刺激免疫系统并促进肿瘤细胞的根除。
