唾液酸化刘易斯（a）作为晚期结直肠癌患者的一种新的预后因素的表达

Expression of sialyl Lewis(a) as a new prognostic factor for patients with advanced colorectal carcinoma.

作者信息

Nakayama T, Watanabe M, Katsumata T, Teramoto T, Kitajima M

机构信息

Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.

出版信息

Cancer. 1995 Apr 15;75(8):2051-6. doi: 10.1002/1097-0142(19950415)75:8<2051::aid-cncr2820750804>3.0.co;2-4.

DOI:10.1002/1097-0142(19950415)75:8<2051::aid-cncr2820750804>3.0.co;2-4

PMID:7697593

Abstract

BACKGROUND

Sialyl Lewis(a) antigen (SLA) is considered to be a cancer-associated carbohydrate antigen.

METHODS

A total of 309 surgically resected primary colorectal cancer specimens and 501 associated metastases to regional lymph nodes were analyzed immunohistochemically using a monoclonal antibody (NS19-9) recognizing SLA. The specimens were obtained from 1981 to 1988 at the Department of Surgery, Keio University School of Medicine (Tokyo, Japan).

RESULTS

Sialyl Lewis(a) antigen expression was detected in 75.4% (233/309) of the primary tumors and in 78.5% (99/126) of the metastases to regional lymph nodes. Significantly stronger expression was noted in the regional lymph node metastases than in the primary lesions (P = 4.5E-7). Sialyl Lewis(a) antigen expression in the primary tumors correlated significantly with regional lymph node metastasis (P < 0.005), recurrence (P < 0.005), and postoperative survival (P < 0.001) as determined by univariate analysis. Sialyl Lewis(a) antigen expression in the regional lymph node metastases also correlated strongly with recurrence (P < 0.005) and survival (P < 0.01). As determined by multivariate analysis, SLA expression in the primary tumor correlated strongly with recurrence (P = 3.0E-6) and survival (P = 6.9E-3).

CONCLUSIONS

Sialyl Lewis(a) antigen expression in primary tumors and metastases to regional lymph nodes is a useful marker for evaluating tumor aggressiveness and prognosis in patients with advanced colorectal cancer.

摘要

背景

唾液酸化路易斯（a）抗原（SLA）被认为是一种癌症相关的碳水化合物抗原。

方法

使用识别SLA的单克隆抗体（NS19 - 9）对309例手术切除的原发性结直肠癌标本和501例相关区域淋巴结转移灶进行免疫组织化学分析。这些标本于1981年至1988年在庆应义塾大学医学院外科（日本东京）获取。

结果

在75.4%（233/309）的原发性肿瘤和78.5%（99/126）的区域淋巴结转移灶中检测到唾液酸化路易斯（a）抗原表达。区域淋巴结转移灶中的表达明显强于原发性病变（P = 4.5E - 7）。单因素分析显示，原发性肿瘤中唾液酸化路易斯（a）抗原表达与区域淋巴结转移（P < 0.005）、复发（P < 0.005）和术后生存率（P < 0.001）显著相关。区域淋巴结转移灶中唾液酸化路易斯（a）抗原表达也与复发（P < 0.005）和生存率（P < 0.01）密切相关。多因素分析表明，原发性肿瘤中SLA表达与复发（P = 3.0E - 6）和生存率（P = 6.9E - 3）密切相关。