Nakayama T, Watanabe M, Katsumata T, Teramoto T, Kitajima M
Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.
Cancer. 1995 Apr 15;75(8):2051-6. doi: 10.1002/1097-0142(19950415)75:8<2051::aid-cncr2820750804>3.0.co;2-4.
Sialyl Lewis(a) antigen (SLA) is considered to be a cancer-associated carbohydrate antigen.
A total of 309 surgically resected primary colorectal cancer specimens and 501 associated metastases to regional lymph nodes were analyzed immunohistochemically using a monoclonal antibody (NS19-9) recognizing SLA. The specimens were obtained from 1981 to 1988 at the Department of Surgery, Keio University School of Medicine (Tokyo, Japan).
Sialyl Lewis(a) antigen expression was detected in 75.4% (233/309) of the primary tumors and in 78.5% (99/126) of the metastases to regional lymph nodes. Significantly stronger expression was noted in the regional lymph node metastases than in the primary lesions (P = 4.5E-7). Sialyl Lewis(a) antigen expression in the primary tumors correlated significantly with regional lymph node metastasis (P < 0.005), recurrence (P < 0.005), and postoperative survival (P < 0.001) as determined by univariate analysis. Sialyl Lewis(a) antigen expression in the regional lymph node metastases also correlated strongly with recurrence (P < 0.005) and survival (P < 0.01). As determined by multivariate analysis, SLA expression in the primary tumor correlated strongly with recurrence (P = 3.0E-6) and survival (P = 6.9E-3).
Sialyl Lewis(a) antigen expression in primary tumors and metastases to regional lymph nodes is a useful marker for evaluating tumor aggressiveness and prognosis in patients with advanced colorectal cancer.
唾液酸化路易斯（a）抗原（SLA）被认为是一种癌症相关的碳水化合物抗原。
使用识别SLA的单克隆抗体（NS19 - 9）对309例手术切除的原发性结直肠癌标本和501例相关区域淋巴结转移灶进行免疫组织化学分析。这些标本于1981年至1988年在庆应义塾大学医学院外科（日本东京）获取。
在75.4%（233/309）的原发性肿瘤和78.5%（99/126）的区域淋巴结转移灶中检测到唾液酸化路易斯（a）抗原表达。区域淋巴结转移灶中的表达明显强于原发性病变（P = 4.5E - 7）。单因素分析显示，原发性肿瘤中唾液酸化路易斯（a）抗原表达与区域淋巴结转移（P < 0.005）、复发（P < 0.005）和术后生存率（P < 0.001）显著相关。区域淋巴结转移灶中唾液酸化路易斯（a）抗原表达也与复发（P < 0.005）和生存率（P < 0.01）密切相关。多因素分析表明，原发性肿瘤中SLA表达与复发（P = 3.0E - 6）和生存率（P = 6.9E - 3）密切相关。
原发性肿瘤和区域淋巴结转移灶中唾液酸化路易斯（a）抗原表达是评估晚期结直肠癌患者肿瘤侵袭性和预后的有用标志物。
