Shlosberg A, Egyed M N, Eilat A, Malkinson M, Preissler E
Avian Dis. 1976 Jan-Mar;20(1):162-6.
The antidotal efficacy of pralidoxime iodide and obidoxime dichloride was investigated in goslings poisoned by a supralethal dose of the organophosphorus insecticide diazinon. Various doses of both drugs were administered by intramuscular injection when the poisoned birds were unable to walk. Pralidoxime at 100 mg/kg brought about a complete and speedy clinical recovery. Fifty mg/kg induced recovery in 4 of 6 poisoned goslings, and 25 mg/kg successfully trated only 1 of 6 birds. Obidoxime at 25 mg/kg showed no therapeutic properties whereas 50 and 100 mg/kg delayed the death of some birds by several hours. At 100 mg/kg, all goslings had transient signs of intoxication, which precluded the use of this compound as an antidote at higher doses. The mode of action of these antidotes in diazinon-poisoned goslings is discussed.
研究了碘解磷定和双复磷对经超致死剂量有机磷杀虫剂二嗪农中毒的雏鹅的解毒效果。当中毒雏鹅无法行走时，通过肌肉注射给予两种药物的不同剂量。100mg/kg的碘解磷定使雏鹅实现了完全且迅速的临床恢复。50mg/kg使6只中毒雏鹅中的4只恢复，而25mg/kg仅成功治疗了6只雏鹅中的1只。25mg/kg的双复磷未显示出治疗效果，而50mg/kg和100mg/kg使一些雏鹅的死亡延迟了数小时。100mg/kg时，所有雏鹅都出现了短暂的中毒迹象，这使得该化合物无法在更高剂量下用作解毒剂。讨论了这些解毒剂在二嗪农中毒雏鹅中的作用方式。
