Ishida H, Kinoshita S, Yamamoto N, Nukaya H, Tsuji K, Kosuge T
School of Pharmaceutical Science, University of Shizuoka, Japan.
Chem Pharm Bull (Tokyo). 1994 Dec;42(12):2532-5. doi: 10.1248/cpb.42.2532.
The effects of scymnol, chimaerol and sodium scymnol sulfate, prepared from the bile of Rhizoprionodon acutus, on cerebral anoxia were investigated in experimental models of hypoxia, ischemia and histotoxic anoxia in mice. Scymnol, at a dose of 100 mg/kg, showed a significant protective action against cerebral anoxia in all of the models studied and significantly increased the partial oxygen pressure of the arterial blood. The anti-anoxic activity of scymnol was found to be slightly greater than that of idevenone. A similar protective effect of sodium scymnol sulfate was seen at doses higher than 100 mg/kg. The survival time on hypoxia was significantly prolonged in the animals pretreated with chimaerol.
从尖吻斜齿鲨胆汁中制备的鲨胆醇、异鲨胆醇和鲨胆醇硫酸酯钠对小鼠低氧、缺血和组织中毒性缺氧实验模型脑缺氧的影响进行了研究。鲨胆醇剂量为100mg/kg时，在所有研究模型中均显示出对脑缺氧的显著保护作用，并显著提高动脉血的血氧分压。发现鲨胆醇的抗缺氧活性略高于艾地苯醌。鲨胆醇硫酸酯钠在高于100mg/kg的剂量时观察到类似的保护作用。用异鲨胆醇预处理的动物在缺氧时的存活时间显著延长。
