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Synthesis of 9E- and 9Z-locked retinoic acid analogs as ligands for RAR and RXR.

作者信息

Katsuta Y, Aoyama Y, Osone H, Wada A, Uchiyama S, Kitamoto T, Masushige S, Kato S, Ito M

机构信息

Kobe Pharmaceutical University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1994 Dec;42(12):2659-61. doi: 10.1248/cpb.42.2659.

DOI:10.1248/cpb.42.2659
PMID:7697779
Abstract

New retinoic acid (RA) analogs 9E-locked-RA 3 and 9Z-locked-RA 4 were synthesized from dithiane 6 and beta-cyclocitral 13, respectively. Both analogs behaved as agonistic ligands for a mixture of retinoic acid receptor (RAR) and retinoid X receptor (RXR).

摘要

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