Kuwamura M, Yoshida T, Yamate J, Kotani T, Sakuma S
Department of Veterinary Pathology, College of Agriculture, University of Osaka Prefecture, Japan.
Brain Res Dev Brain Res. 1994 Dec 16;83(2):294-8. doi: 10.1016/0165-3806(94)00167-7.
We report a new rat model of hereditary cerebellar vermis defect. Mutant rats exhibited hind-leg paralysis from about 14 days old. Gross pathology showed the cerebellar vermis defect, fused cerebellar hemispheres and cyst formation. Ectopic dysplastic cerebellar tissues existed in the cerebello-pontine junctional zones. Mild disarrangement of lamination was also observed in the fused cerebellar hemispheres. The present mutant may serve as a valid model for studying the cerebellar vermis defect under the genetic control.
