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High mutagenicity and toxicity of a diol epoxide derived from benzo(a)pyrene.

作者信息

Wislocki P G, Wood A W, Chang R L, Levin W, Yagi H, Hernandez O, Jerina D M, Conney A H

出版信息

Biochem Biophys Res Commun. 1976 Feb 9;68(3):1006-12. doi: 10.1016/0006-291x(76)91246-8.

DOI:10.1016/0006-291x(76)91246-8
PMID:769789
Abstract
摘要

相似文献

1
High mutagenicity and toxicity of a diol epoxide derived from benzo(a)pyrene.
Biochem Biophys Res Commun. 1976 Feb 9;68(3):1006-12. doi: 10.1016/0006-291x(76)91246-8.
2
Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells.苯并[a]芘和苯并[a]蒽的异构二醇环氧化物在鼠伤寒沙门氏菌TA98和TA100以及V79中国仓鼠细胞中的诱变性。
Mutat Res. 1977 Sep;44(3):313-26. doi: 10.1016/0027-5107(77)90091-4.
3
Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.苯并(a)芘苯环环氧化物的致突变性和细胞毒性。
Cancer Res. 1976 Sep;36(9 pt.1):3358-66.
4
Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acid.天然存在的植物酚类对多环芳烃湾区二醇环氧化物致突变性的抑制作用:鞣花酸的卓越活性。
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5513-7. doi: 10.1073/pnas.79.18.5513.
5
Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides.非对映体苯并[a]芘7,8-二醇-9,10-环氧化物光学对映体的诱变性差异。
Biochem Biophys Res Commun. 1977 Aug 22;77(4):1389-96. doi: 10.1016/s0006-291x(77)80133-2.
6
Mutagenicity of K-region epoxides of polycyclic aromatic compounds: structure-activity relationship.
Mutat Res. 1976 Nov;37(2-3):187-91. doi: 10.1016/0027-5107(76)90032-4.
7
Mutagenicity of the bay-region diol-epoxides and other benzo-ring derivatives of dibenzo(a,h)pyrene and dibenzo(a,i)pyrene.二苯并(a,h)芘和二苯并(a,i)芘的湾区二醇环氧化物及其他苯环衍生物的诱变性。
Cancer Res. 1981 Jul;41(7):2589-97.
8
Mutagenicity of aryl propylene and butylene oxides with salmonella.
Mutat Res. 1987 Nov;189(3):189-204. doi: 10.1016/0165-1218(87)90053-x.
9
The induction of sister-chromatid exchanges in Chinese hamster ovary cells by some epoxides and phenolic derivatives of benzo[a]pyrene.苯并[a]芘的某些环氧化物和酚类衍生物对中国仓鼠卵巢细胞姐妹染色单体交换的诱导作用。
Mutat Res. 1980 Jun;78(2):193-9. doi: 10.1016/0165-1218(80)90098-1.
10
Relationships of quantum mechanical calculations, relative mutagenicity of benzo[a]anthracene diol epoxides, and "bay region" concept of aromatic hydrocarbon carcinogenicity.量子力学计算、苯并[a]蒽二醇环氧化物的相对诱变性与芳烃致癌性“湾区”概念之间的关系。
J Toxicol Environ Health. 1977 Jul;2(6):1259-65. doi: 10.1080/15287397709529528.

引用本文的文献

1
Evolution of activation-detoxification enzyme patterns during precarcinogenesis in synergism: 3-methylcholanthrene and dimethylnitrosamine.协同作用下致癌前阶段激活 - 解毒酶模式的演变:3 - 甲基胆蒽与二甲基亚硝胺
J Cancer Res Clin Oncol. 1982;103(3):227-40. doi: 10.1007/BF00409699.
2
Epoxides--is there a human health problem?环氧化合物——存在人类健康问题吗?
Br J Ind Med. 1980 Nov;37(4):317-36. doi: 10.1136/oem.37.4.317.
3
Epoxidation reactions catalyzed by rat liver cytochromes P-450 and P-448 occur at different faces of the 8,9-double bond of 8-methylbenz[a]anthracene.
大鼠肝细胞色素P-450和P-448催化的环氧化反应发生在8-甲基苯并[a]蒽的8,9-双键的不同面上。
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6802-6. doi: 10.1073/pnas.79.22.6802.
4
Specificity in interaction of benzo[a]pyrene with nuclear macromolecules: implication of derivatives of two dihydrodiols in protein binding.苯并[a]芘与核大分子相互作用的特异性:两种二氢二醇衍生物在蛋白质结合中的意义。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6396-400. doi: 10.1073/pnas.77.11.6396.
5
Specificity of chemiluminescence in the metabolism of benzo[a]pyrene to its carcinogenic diol epoxide.苯并[a]芘代谢为其致癌二醇环氧化物过程中化学发光的特异性。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):940-2. doi: 10.1073/pnas.78.2.940.
6
Effect of histone acetylation on the formation and removal of B(a)P chromatin adducts.组蛋白乙酰化对苯并[a]芘染色质加合物形成与去除的影响。
Nucleic Acids Res. 1982 May 11;10(9):2775-89. doi: 10.1093/nar/10.9.2775.
7
Base insertion and deletion mutations induced in an Escherichia coli plasmid by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.苯并[a]芘-7,8-二氢二醇-9,10-环氧化物在大肠杆菌质粒中诱导产生的碱基插入和缺失突变。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6817-20. doi: 10.1073/pnas.78.11.6817.
8
Formation and persistence of benzo(a)pyrene metabolite-DNA adducts.苯并(a)芘代谢物-DNA加合物的形成与持久性。
Environ Health Perspect. 1985 Oct;62:31-9. doi: 10.1289/ehp.856231.
9
Significance of various enzymes in the control of reactive metabolites.各种酶在活性代谢物控制中的意义。
Arch Toxicol. 1987;60(1-3):174-8. doi: 10.1007/BF00296975.
10
(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice.(±)-反式-7,8-二羟基-7,8-二氢苯并(a)芘:局部应用于小鼠时是一种强效皮肤致癌物。
Proc Natl Acad Sci U S A. 1976 Nov;73(11):3867-71. doi: 10.1073/pnas.73.11.3867.