Modi W S, Farrar W L, Howard O M
Biological Carcinogenesis and Development Program, Program Resources Inc./DynCorp., NCI-Frederick Cancer Research and Development Center, MD 21702-1201, USA.
Cytogenet Cell Genet. 1995;69(3-4):232-4. doi: 10.1159/000133971.
JAK1A is a recently isolated class 3 (nonreceptor) tyrosine kinase that has catalytic domain sequence homology with other kinases and is known to be ubiquitously expressed in all human tissues thus far examined. The gene for this enzyme had previously been localized to chromosome 1 using somatic cell hybrids and linkage analyses. In the present study, fluorescence in situ hybridization was utilized to confirm its localization and regionally assign the gene to chromosome region 1p32.3-->p31.3.
JAK1A是一种最近分离出的3类（非受体）酪氨酸激酶，其催化结构域序列与其他激酶具有同源性，并且已知在迄今为止检测的所有人体组织中均有广泛表达。此前，利用体细胞杂交和连锁分析已将该酶的基因定位到1号染色体。在本研究中，采用荧光原位杂交技术来确认其定位，并将该基因区域定位到染色体区域1p32.3→p31.3。
