Bespalov A, Dumpis M, Piotrovsky L, Zvartau E
Department of Pharmacology, Pavlov Medical University, St.-Petersburg, Russian Federation.
Eur J Pharmacol. 1994 Nov 3;264(3):233-9. doi: 10.1016/0014-2999(94)00462-5.
The effect of the non-selective antagonist of excitatory amino acid receptors kynurenic acid (50, 100 and 150 mg/kg, i.p.) on morphine-derived reward was studied in rats. Kynurenic acid dose dependently blocked the acquisition of morphine conditioned place preference when injected before conditioning. The expression of the previously established conditioned behavior was also blocked by the pretreatment with kynurenic acid (at the doses which do not reduce spontaneous locomotor activity) before testing. In the control experiments we failed to find that kynurenic acid alone exerts positive place preference conditioning or aversion. Kynurenic acid also attenuated the morphine-induced facilitation of responding in the intracranial self-stimulation test, causing a decrease in response rate and an increase in threshold current intensity. This effect was observed with doses at which kynurenic acid does not affect responding in the self-stimulation test by itself.
在大鼠中研究了兴奋性氨基酸受体的非选择性拮抗剂犬尿喹啉酸（50、100和150毫克/千克，腹腔注射）对吗啡诱导奖赏效应的影响。在条件反射训练前注射犬尿喹啉酸，其剂量依赖性地阻断了吗啡条件性位置偏爱效应的获得。在测试前用犬尿喹啉酸预处理（剂量不降低自发运动活性）也阻断了先前建立的条件性行为的表达。在对照实验中，我们未发现单独使用犬尿喹啉酸会产生阳性位置偏爱条件反射或厌恶效应。犬尿喹啉酸还减弱了吗啡在颅内自我刺激试验中对反应的促进作用，导致反应率降低和阈电流强度增加。在犬尿喹啉酸本身不影响自我刺激试验中反应的剂量下观察到了这种效应。
