De Almeida R M, Lucion A B
Department of Physiology, Institute of Biological Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Eur J Pharmacol. 1994 Nov 3;264(3):445-8. doi: 10.1016/0014-2999(94)00548-6.
This study attempted to analyze the effects of 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), TFMPP (1-(3-trifluoromethyl-phenyl)piperazine hydrochloride), and DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) on maternal aggressive behavior. Female Wistar rats were divided into 4 groups of 12 animals each. They received an intracerebroventricular (i.c.v.) injection of: (1) saline, (2) 8-OH-DPAT (20 micrograms/rat), (3) TFMPP (100 micrograms/rat), and (4) DOI (100 micrograms/rat). 5-HT1A (8-OH-DPAT) and 5-HT2 (DOI) receptor agonists decreased the frequency of attack 15 but not 55 min after i.c.v. injection. The 5-HT1B/D receptor agonist (TFMPP), in the dose studied, showed no significant difference as compared to saline. Pup care and non-aggressive social interaction with the intruder were not affected by any drug. These data suggest that 5-HT1A and 5-HT2 receptor agonists can specifically inhibit maternal aggression without affecting maternal care; however, this effect is of short duration.
本研究试图分析8-OH-DPAT（8-羟基-2-（二正丙基氨基）四氢萘）、TFMPP（1-（3-三氟甲基苯基）哌嗪盐酸盐）和DOI（1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷）对母鼠攻击行为的影响。将雌性Wistar大鼠分为4组，每组12只。它们接受脑室内（i.c.v.）注射：（1）生理盐水，（2）8-OH-DPAT（20微克/只大鼠），（3）TFMPP（100微克/只大鼠），以及（4）DOI（100微克/只大鼠）。5-HT1A（8-OH-DPAT）和5-HT2（DOI）受体激动剂在脑室内注射后15分钟而非55分钟降低了攻击频率。在所研究的剂量下，5-HT1B/D受体激动剂（TFMPP）与生理盐水相比无显著差异。幼崽护理以及与入侵者的非攻击性社会互动均未受到任何药物的影响。这些数据表明，5-HT1A和5-HT2受体激动剂可特异性抑制母鼠的攻击行为而不影响母性护理；然而，这种作用持续时间较短。
