辐射对宫颈癌患者血清糖蛋白和糖苷酶的影响。
Effect of radiation on serum glycoproteins and glycosidases in patients with cervical carcinoma.
作者信息
Bhuvarahamurthy V, Balasubramanian N, Vijayakumar S, Govindasamy S
机构信息
Cancer Biology Division, School of Biological Sciences, Madurai Kamaraj University, India.
出版信息
Int J Gynaecol Obstet. 1995 Jan;48(1):49-54. doi: 10.1016/0020-7292(94)02247-x.
OBJECTIVE
The serum glycan moieties of glycoproteins and the activities of glycosidases were analyzed in order to elucidate the metabolism of glycoprotein in uterine cervical cancer.
METHODS
Serum was collected from patients at different stages of cervical cancer before and after treatment. The results were analyzed using Student's t-test.
RESULTS
The glycan moieties such as sialic acid and fucose were significantly elevated even in the early stages of carcinoma, whereas a significant elevation in hexose and hexosamine levels was observed only in the advanced stages. Among the investigated lysosomal glycohydrolases, beta-D-galactosidase, N-acetyl-beta-D-glucosaminidase and alpha-L-fucosidase activities were elevated significantly at all stages except for stage I. The altered levels of glycoproteins and glycosidases were reduced to near-normal levels after radiotherapy.
CONCLUSION
The levels of glycan moieties and the activities of glycosidases can be used as diagnostic markers to assess the stage of cancer and can be used as prognostic markers during therapy.
目的
分析糖蛋白的血清聚糖部分及糖苷酶活性，以阐明子宫颈癌中糖蛋白的代谢情况。
方法
收集宫颈癌不同阶段患者治疗前后的血清。结果采用学生t检验进行分析。
结果
即使在癌症早期，唾液酸和岩藻糖等聚糖部分也显著升高，而仅在晚期观察到己糖和己糖胺水平显著升高。在所研究的溶酶体糖苷水解酶中，除I期外，β-D-半乳糖苷酶、N-乙酰-β-D-氨基葡萄糖苷酶和α-L-岩藻糖苷酶活性在所有阶段均显著升高。放疗后，糖蛋白和糖苷酶的改变水平降至接近正常水平。
结论
聚糖部分水平和糖苷酶活性可作为评估癌症分期的诊断标志物，并可在治疗期间作为预后标志物。
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