Upadhya Sharmila, Upadhya Subramanya, Prabhu K S
Department of Biochemistry, Kasturba Medical College, 576 119 Manipal.
Indian J Clin Biochem. 2002 Jan;17(1):20-4. doi: 10.1007/BF02867936.
The present study was done to assess the levels of glycoconjugates and ceruloplasmin in sera of patients with cervical cancer. Serum hexoses, hexosamines, sialic acid and fucose are elevated in a variety of inflammatory and neoplastic conditions. All the glycoconjugates, except fucose were increased in serum of patients compared to controls. Also, hexoses and sialic acid levels were high in patients with later stages of cancer compared to patients with early stage disease (P=<0.0001, P=0.03). Serum ceruloplasmin was increased in patients with early stage cancer (51.5mg/dl) and with late stage cancer (61mg/dl) compared to controls (38mg/dl). The elevated glycoconjugates may be the result of inflammatory reaction associated with neoplasia, as serum ceruloplasmin (an acute phase reactant) is also increased in these patients.
本研究旨在评估宫颈癌患者血清中糖结合物和铜蓝蛋白的水平。血清己糖、氨基己糖、唾液酸和岩藻糖在多种炎症和肿瘤性疾病中均会升高。与对照组相比，患者血清中除岩藻糖外的所有糖结合物均增加。此外，与早期癌症患者相比，癌症晚期患者的己糖和唾液酸水平更高（P<0.0001，P=0.03）。与对照组（38mg/dl）相比，早期癌症患者（51.5mg/dl）和晚期癌症患者（61mg/dl）的血清铜蓝蛋白均升高。糖结合物升高可能是与肿瘤形成相关的炎症反应的结果，因为这些患者的血清铜蓝蛋白（一种急性期反应物）也增加。
