Stefanis C N, Issidorides M R
Biol Psychiatry. 1976 Feb;11(1):53-68.
Chromatin structure and nucleohistone pattern were investigated histochemically in the neutrophils of 11 schizophrenics and 16 healthy controls. Compared to controls, all schizophrenic parents prior to medication showed a distinctly different histochemical pattern consisting of increased concentration and abnormal distribution of nucleohistones. This pattern has been attributed to an increase of arginine-rich histones in schizophrenics. Pimozide administration exerted a normalizing effect on the nucleohistone distribution pattern. These findings further support our view that genomic expression abnormalities may be related to schizophrenic illness.
对11名精神分裂症患者和16名健康对照者的中性粒细胞进行了组织化学研究，以探讨染色质结构和核组蛋白模式。与对照组相比，所有未用药的精神分裂症患者均表现出明显不同的组织化学模式，包括核组蛋白浓度增加和分布异常。这种模式归因于精神分裂症患者中富含精氨酸的组蛋白增加。服用匹莫齐特对核组蛋白分布模式产生了正常化作用。这些发现进一步支持了我们的观点，即基因组表达异常可能与精神分裂症有关。
