Gregor M
Abteilung für Innere Medizin I, Eberhard-Karls-Universität, Tübingen, Deutschland.
Digestion. 1994;55 Suppl 3:60-3. doi: 10.1159/000201203.
Malignant carcinoid syndrome is characterized most commonly by flushing and diarrhea of varying severity when tumors metastasize to the liver. Besides supportive measures for mild symptoms, the pharmacological management includes drugs to inhibit synthesis, release or peripheral actions of the circulating tumor products either alone or in combination. Among those agents octreotide, a synthetic long-acting analogue of somatostatin, is the drug of choice because it has proved useful for ameliorating symptoms in most patients with this syndrome. Although there is a multitude of potential and actual side effects, this antihormonal drug is very well tolerated and is a significant advance in therapy.
恶性类癌综合征最常见的特征是当肿瘤转移至肝脏时出现程度各异的潮红和腹泻。除了针对轻微症状的支持性措施外，药物治疗包括单独或联合使用抑制循环肿瘤产物合成、释放或外周作用的药物。在这些药物中，奥曲肽，一种合成的长效生长抑素类似物，是首选药物，因为它已被证明对改善大多数该综合征患者的症状有用。尽管有许多潜在和实际的副作用，但这种抗激素药物耐受性良好，是治疗上的一项重大进展。
