Bergenfelz A, Ahrén B
Department of Surgery, Lund University, Sweden.
Horm Res. 1994;42(6):273-7. doi: 10.1159/000184208.
It has been suggested that calcium changes the set point of the pituitary thyroid feedback. It is not known, however, if small and slow changes of calcium and/or parathyroid hormone (PTH) within the physiological range influence the serum levels of thyrotropin (TSH) and thyroid hormones in healthy subjects or patients with primary hyperparathyroidism (pHPT). Nine healthy subjects and nine patients with pHPT were therefore investigated with an oral calcium load test. The patients were investigated before and 4 days after operation. During the test, serum levels of ionized calcium increased and serum levels of intact PTH decreased in both healthy subjects and patients pre- and postoperatively (p < 0.001). Furthermore, in patients, the suppressibility of serum levels of PTH by calcium increased postoperatively (p < 0.05). Serum levels of TSH decreased during the oral calcium load in healthy subjects (p < 0.01) but not in patients, whereas the serum levels of thyroid hormones did not change. It is concluded that oral calcium influences TSH secretion in healthy humans but not in patients with pHPT.
有人提出钙会改变垂体 - 甲状腺反馈的设定点。然而，尚不清楚生理范围内钙和/或甲状旁腺激素（PTH）的微小缓慢变化是否会影响健康受试者或原发性甲状旁腺功能亢进症（pHPT）患者的促甲状腺激素（TSH）和甲状腺激素血清水平。因此，对9名健康受试者和9名pHPT患者进行了口服钙负荷试验。在手术前和手术后4天对患者进行了调查。在试验期间，健康受试者以及术前和术后患者的血清离子钙水平均升高，血清完整PTH水平均降低（p < 0.001）。此外，在患者中，术后钙对血清PTH水平的抑制作用增强（p < 0.05）。在健康受试者中，口服钙负荷期间TSH血清水平降低（p < 0.01），但在患者中未降低，而甲状腺激素血清水平没有变化。得出的结论是，口服钙会影响健康人的TSH分泌，但不会影响pHPT患者的TSH分泌。
