Ada G
Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra.
Immunol Cell Biol. 1994 Dec;72(6):447-54. doi: 10.1038/icb.1994.68.
Twenty years ago, the terms 'altered self' and 'H-2 restriction', later modified to 'MHC-restriction', were coined to describe the finding by Peter Doherty and Rolf Zinkernagel that murine cytotoxic T cells (CTL) would lyse virus-infected target cells only if effector and target cells were H-2 compatible. This short review recalls those heady days and briefly recounts some of the later findings in three aspects of particular interest raised by the original finding: the nature of the T cell receptor, the composition and structure of the ligand on the target cell recognized by the TCR and the importance of CTL in the control and clearance of infections in general.
二十年前，“改变的自身”和“H-2限制”（后来修改为“MHC限制”）这两个术语被创造出来，用以描述彼得·多尔蒂（Peter Doherty）和罗尔夫·津克纳格尔（Rolf Zinkernagel）的发现，即小鼠细胞毒性T细胞（CTL）只有在效应细胞和靶细胞的H-2相容时才会裂解病毒感染的靶细胞。这篇简短的综述回顾了那些令人兴奋的日子，并简要叙述了由最初的发现引发的三个特别有趣的方面的一些后续研究结果：T细胞受体的性质、TCR识别的靶细胞上配体的组成和结构，以及CTL在总体上控制和清除感染中的重要性。
