Fadda M, Manunta A, Rinonapoli G, Zirattu G, De Santis E
Orthopaedic Department, University of Sassari, Italy.
Int Orthop. 1994;18(6):389-92. doi: 10.1007/BF00187088.
The ultrastructural appearance of two chondroblastoma were examined by scanning and transmission electron microscopy. The polygonal basal cells, with a scanty pericellular matrix, show a poorly developed endoplasmic reticulum and many Golgi bodies. The highly differentiated chondroid cells are assembled in isogenous clusters and show intracytoplasmic inclusions of glycogen and lipids, numerous mitochondria and superficial secretion vesicles arising from a well developed rough endoplasmic reticulum. Clusters of crystals, in close contact with the matrix collagen fibres are found near to the tumour cells. These ultrastructural characteristics, together with the basal undifferentiated cells that proliferate and differentiate into cartilaginous tissue, distinguish this neoplasm from chondroma, mesenchymal chondrosarcoma and chondromyxoid fibroma and confirm its chondroid origin.
通过扫描电子显微镜和透射电子显微镜对两例软骨母细胞瘤的超微结构进行了检查。多边形的基底细胞周围基质稀少，内质网发育不良，有许多高尔基体。高度分化的类软骨细胞聚集形成同源细胞群，胞质内有糖原和脂质包涵体、大量线粒体以及由发育良好的粗面内质网产生的表面分泌小泡。在肿瘤细胞附近发现了与基质胶原纤维紧密接触的晶体簇。这些超微结构特征，连同增殖并分化为软骨组织的基底未分化细胞，将该肿瘤与软骨瘤、间叶性软骨肉瘤和软骨黏液样纤维瘤区分开来，并证实了其类软骨起源。
