氟氢可的松治疗糖尿病性体位性低血压的经验
Therapeutic experience with fludrocortisone in diabetic postural hypotension.
作者信息
Campbell I W, Ewing D J, Clarke B F
出版信息
Br Med J. 1976 Apr 10;1(6014):872-4. doi: 10.1136/bmj.1.6014.872.
Abstract
Fourteen patients with diabetic postural hypotension were treated with fludrocortisone for a mean 12 months (range 6-30 months). The mean daily dose of fludrocortisone was 0.2 mg (range 0.1 mg-0.4 mg). Standing systolic and diastolic blood pressures increased significantly (P less than 0.001) after treatment with fludrocortisone and the postural hypotension decreased significantly (P less than 0.001). Thirteen patients noted considerable symptomatic improvement. Fludrocortisone should be used cautiously in patients with congestive cardiac failure or the nephrotic syndrome.
摘要
14例糖尿病性体位性低血压患者接受氟氢可的松治疗，平均治疗12个月（范围6 - 30个月）。氟氢可的松的平均日剂量为0.2毫克（范围0.1毫克 - 0.4毫克）。使用氟氢可的松治疗后，站立位收缩压和舒张压显著升高（P < 0.001），体位性低血压显著降低（P < 0.001）。13例患者症状有明显改善。充血性心力衰竭或肾病综合征患者应谨慎使用氟氢可的松。
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本文引用的文献
1
Successful treatment of orthostatic hypotension with 9-alpha-fluorohydrocortisone.用9-α-氟氢化可的松成功治疗体位性低血压。
N Engl J Med. 1959 Oct 15;261:788-91. doi: 10.1056/NEJM195910152611604.
2
IDIOPATHIC ORTHOSTATIC HYPOTENSION. DIAGNOSIS AND TREATMENT.特发性直立性低血压。诊断与治疗。
JAMA. 1963 Nov 9;186:537-40. doi: 10.1001/jama.1963.03710060023005.
3
Effect of 9-alpha-fluorohydrocortisone on forearm vascular responses to norepinephrine.
Circulation. 1966 Oct;34(4):620-6. doi: 10.1161/01.cir.34.4.620.
4
Orthostatic hypotension. Treatment with sodium chloride and sodium retaining steroid hormones.
Arch Intern Med. 1968 Dec;122(6):467-71. doi: 10.1001/archinte.122.6.467.
5
Extensive autonomic neuropathy in diabetes.糖尿病中的广泛自主神经病变。
Proc R Soc Med. 1971 Aug;64(8):803-4. doi: 10.1177/003591577106400801.
6
Decreased response of plasma renin activity to orthostasis in diabetic patients with orthostatic hypotension.
Diabetes. 1974 Oct;23(10):835-40. doi: 10.2337/diab.23.10.835.
7
An assessment of various methods of treatment of idiopathic orthostatic hypotension.
Q J Med. 1969 Oct;38(152):377-95.
8
Vascular reflexes in diabetic autonomic neuropathy.糖尿病自主神经病变中的血管反射
Lancet. 1973 Dec 15;2(7842):1354-6. doi: 10.1016/s0140-6736(73)93323-0.
9
Degeneration of the autonomic nervous system.
Lancet. 1971 Jul 24;2(7717):175-9. doi: 10.1016/s0140-6736(71)90893-2.
10
9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy.9-α-氟氢化可的松治疗糖尿病性自主神经病变所致体位性低血压
Diabetes. 1975 Apr;24(4):381-4. doi: 10.2337/diab.24.4.381.
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