肾脏在调节血浆免疫反应性β-黑素细胞刺激素中的作用。
Role of the kidney in regulating plasma immunoreactive beta-melanocyte-stimulating hormone.
作者信息
Smith A G, Shuster S, Thody A J, Alvarez-Ude F, Kerr D N
出版信息
Br Med J. 1976 Apr 10;1(6014):874-6. doi: 10.1136/bmj.1.6014.874.
An analysis of the factors that influence the increase in plasma immunoreactive beta-melanocyte-stimulating hormone (beta-MSH) concentration in chronic renal failure showed that: (a) the increase correlated with the increase in serum creatinine concentrations; (b) beta-MSH was not cleared from the plasma by haemodialysis; (c) beta-MSH concentrations increased with length of time on dialysis and increased further after bilateral nephrectomy but there was no further increase with time; (d) beta-MSH levels decreased to normal after renal transplantation; and (e) beta-MSH was excreted in urine only when plasma levels rose to well above those of chronic renal failure (in Nelson's syndrome). These findings suggest that the kidney regulated plasma beta-MSH by a non-excretory mechanism and is the major site of beta-MSH metabolism.
一项关于影响慢性肾衰竭患者血浆免疫反应性β-黑素细胞刺激素（β-MSH）浓度升高因素的分析表明：（a）该升高与血清肌酐浓度的升高相关；（b）血液透析不能清除血浆中的β-MSH；（c）β-MSH浓度随透析时间延长而升高，双侧肾切除术后进一步升高，但之后不再随时间进一步升高；（d）肾移植后β-MSH水平降至正常；（e）仅当血浆水平升至远高于慢性肾衰竭患者（纳尔逊综合征）时，β-MSH才会随尿液排出。这些发现提示，肾脏通过非排泄机制调节血浆β-MSH，且是β-MSH代谢的主要部位。
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