离子载体X-537A和A-23187对平滑肌的作用。

The action of the ionophores, X-537A and A-23187, on smooth muscle.

作者信息

Swamy V C, Ticku M, Triggle C R, Triggle D J

出版信息

Can J Physiol Pharmacol. 1975 Dec;53(6):1108-14. doi: 10.1139/y75-154.

Abstract

The cation ionophore X-537A in the concentration range of 10(-6) to 3 X 10(-5) M produced contractions in the rat and guinea-pig vas deferens. No contractile effect was produced in either of the vasa deferentia preparations by the ionophore A-23187 in the concentration range of 10(-7) to 5 X 10(-5) M. In contrast, X-537A had no contractile effect on the guinea-pig ileal longitudinal smooth muscle while A-23187 produced a dose and [Ca2+] dependent contraction. The contractile effect of X-537A in the vasa deferentia preparations is abolished by phenoxybenzamine or prior reserpine treatment and is therefore attributed to the release of norepinephrine. The effect of A-23187 in the intestinal smooth muslce is attributed to a direct Ca2+ transporting action since its contractile effect is unaffected by histamine, acetylcholine, or 5-hydroxytryptamine antagonists.

摘要

浓度范围在10⁻⁶至3×10⁻⁵M的阳离子离子载体X - 537A可使大鼠和豚鼠的输精管产生收缩。浓度范围在10⁻⁷至5×10⁻⁵M的离子载体A - 23187对两种输精管制剂均未产生收缩作用。相比之下，X - 537A对豚鼠回肠纵行平滑肌无收缩作用，而A - 23187则产生剂量和[Ca²⁺]依赖性收缩。苯氧苄胺或事先用利血平处理可消除X - 537A在输精管制剂中的收缩作用，因此该作用归因于去甲肾上腺素的释放。A - 23187在肠道平滑肌中的作用归因于其直接的Ca²⁺转运作用，因为其收缩作用不受组胺、乙酰胆碱或5-羟色胺拮抗剂的影响。