Ylikontiola L, Altonen M, Uhari M, Tiilikainen A, Oikarinen K
Department of Oral and Maxillofacial Surgery, University of Oulu, Finland.
Int J Oral Maxillofac Surg. 1994 Dec;23(6 Pt 1):359-62. doi: 10.1016/s0901-5027(05)80055-4.
Identical female twins with chronic sclerosing osteomyelitis of the mandible are presented. The diagnoses of both at the age of 12 years were based on typical history, and on clinical, radiographic, and histologic findings. High concentrations of IgA and IgG were detected in the serum of both patients, but deviations were not observed in other immunologic variables. The normally commensal organism, Propionibacterium acnes grew from a bone biopsy specimen from the mandible of one twin. No oral focus of the disease was confirmed in either case. We suggest that hereditary factors must have played a role in the pathogenesis of these cases of chronic osteomyelitis.
本文报告了一对患有下颌骨慢性硬化性骨髓炎的同卵双胞胎女性。两人在12岁时的诊断均基于典型病史以及临床、影像学和组织学检查结果。两名患者血清中均检测到高浓度的IgA和IgG，但在其他免疫变量中未观察到偏差。从其中一名双胞胎下颌骨的骨活检标本中培养出了通常共生的痤疮丙酸杆菌。两例均未证实存在口腔疾病病灶。我们认为遗传因素在这些慢性骨髓炎病例的发病机制中一定起到了作用。
