Blakemore W F, Franklin R J, Crang A J
Cambridge Centre for Brain Repair, University of Cambridge, UK.
J Neurol. 1994 Dec;242(1 Suppl 1):S61-3. doi: 10.1007/BF00939245.
Transplantation of oligodendrocyte lineage cells results in myelination of naked axons. The most extensive remyelination is achieved using A2B5 positive progenitor cells and these observations encourage the view that glial transplantation may be a useful treatment in human demyelinating diseases. However, several issues need to be resolved before glial cell transplantation can be applied clinically; this review focuses on the choice of cells, their source, whether chronically demyelinated axons can be repaired by transplantation, and whether the principles of glial transplantation established in small rodents are applicable to other mammalian species and to man.
少突胶质细胞系细胞移植可导致裸露轴突的髓鞘形成。使用A2B5阳性祖细胞可实现最广泛的髓鞘再生，这些观察结果支持了胶质细胞移植可能是治疗人类脱髓鞘疾病的有效方法这一观点。然而，在胶质细胞移植能够应用于临床之前，有几个问题需要解决；本综述重点关注细胞的选择、其来源、慢性脱髓鞘轴突是否可通过移植修复，以及在小型啮齿动物中确立的胶质细胞移植原则是否适用于其他哺乳动物物种和人类。
