Pavlidis N, Nicolaides C, Klouvas G, Briassoulis E
Department of Medicine, School of Medicine, University of Ioannina, Greece.
J Chemother. 1994 Dec;6(6):417-22. doi: 10.1080/1120009x.1994.11741177.
The main purpose of this trial was to investigate the activity of a less toxic regimen in patients with advanced gastric carcinoma regarding response rate and survival. We report on a pilot study of 20 patients treated with the combination of 5-fluorouracil and folinic acid. 5-fluorouracil was administered at a daily dose of 450 mg/m2 followed by folinic acid 200 mg/m2 for four consecutive days every four weeks. The overall response rate was 15% with one complete and two partial responders. The median duration of response was 11, 10 and 10 months respectively. The median survival of all patients was 9 months. Toxicity was mild and consisted primarily of diarrhea. Stomatitis and myelosuppression occurred rarely. In conclusion, the combination of 5-fluorouracil and folinic acid has moderate activity in gastric cancer, while median survival appears similar to the other more intensive regimens. The combination is very well tolerated with minimal toxicity. A detailed review of the literature regarding the effectiveness of the above regimens on response rate, overall survival and toxicity is also presented.
本试验的主要目的是研究一种毒性较小的治疗方案对晚期胃癌患者的疗效及生存率。我们报告了一项对20例接受5-氟尿嘧啶和亚叶酸联合治疗患者的初步研究。5-氟尿嘧啶的给药剂量为每日450mg/m²，随后每四周连续四天给予亚叶酸200mg/m²。总缓解率为15%，其中1例完全缓解，2例部分缓解。缓解持续时间中位数分别为11个月、10个月和10个月。所有患者的中位生存期为9个月。毒性较轻，主要为腹泻。口腔炎和骨髓抑制很少发生。总之，5-氟尿嘧啶和亚叶酸联合方案在胃癌治疗中有中等活性，中位生存期与其他更强化的治疗方案相似。该联合方案耐受性良好，毒性极小。本文还对上述治疗方案在缓解率、总生存期和毒性方面的有效性进行了详细的文献综述。
