铊-201在人体睾丸中的动力学与剂量学
Kinetics and dosimetry of thallium-201 in human testes.
作者信息
Rao D V, Shepstone B J, Wilkins H B, Howell R W
机构信息
Department of Radiology, New Jersey Medical School, Newark 07103, USA.
出版信息
J Nucl Med. 1995 Apr;36(4):607-9.
UNLABELLED
Thallous chloride (201Tl) is a well-known imaging agent. It has been shown to accumulate in the testes. In view of this, the testicular kinetics of 201Tl is investigated in humans and the absorbed dose to the organ calculated.
METHODS
Thallous chloride 201Tl was injected intravenously into four patients for myocardial perfusion studies. After clinical evaluation, the testicular uptake and clearance of 201Tl were monitored for about 1 wk using a gamma camera.
RESULTS
Testicular uptake of 201Tl was rapid with a mean biological uptake half-time of 0.67 hr and mean biological clearance half-time of 280 hr. The mean maximum testicular uptake of 201Tl was about 0.4% of the injected activity. These data were utilized to calculate the average absorbed dose to the testes. The absorbed dose to the testes was calculated to be 3.5 x 10(-4) Gy/MBq (1.3 rad/mCi) of injected activity.
CONCLUSION
When the relative biological effectiveness of the Auger emitter 201Tl is taken into account, the equivalent dose to the testes is 9.5 x 10(-4) Sv/MBq (3.5 rem/mCi).
未标记
氯化铊（201Tl）是一种知名的显像剂。已证实它会在睾丸中蓄积。鉴于此，对201Tl在人体中的睾丸动力学进行了研究，并计算了该器官的吸收剂量。
方法
将氯化铊201Tl静脉注射到4名患者体内进行心肌灌注研究。临床评估后，使用γ相机监测201Tl的睾丸摄取和清除情况约1周。
结果
201Tl的睾丸摄取迅速，平均生物摄取半衰期为0.67小时，平均生物清除半衰期为280小时。201Tl的平均最大睾丸摄取量约为注射活度的0.4%。利用这些数据计算睾丸的平均吸收剂量。计算得出睾丸的吸收剂量为3.5×10−4 Gy/MBq（1.3 rad/mCi）注射活度。
结论
考虑到俄歇发射体201Tl的相对生物效能，睾丸的当量剂量为9.5×10−4 Sv/MBq（3.5 rem/mCi）。
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