Pilch L, Stewart C, Gordon D, Inman R, Parsons K, Pataki I, Stevens J
Eye Research Institute of Canada, Toronto Hospital, ON.
J Rheumatol. 1994 Dec;21(12):2307-21.
Our goal was the development of an accurate and objective technique to depict and quantitate articular cartilage using magnetic resonance imaging (MRI) and 3D data processing.
A method of 3D image analysis has been developed that provides a noninvasive technique of measuring cartilage volume from standard diagnostic MR images.
Using a computer workstation, cartilage from Fast Field Echo (FFE) MR images was reconstructed into 3 dimensions (3D). The accuracy and reproducibility of both thickness and volume measurements obtained from the existing computer software was tested using calibration test objects. We describe the sources of error we encountered when attempting to quantitate cartilage using the existing computer software, the methods developed to reduce these errors, and a preliminary cartilage volume study using healthy human volunteers.
We have identified errors involved in attempting cartilage volume estimations using the existing 3D computer software and have developed a data processing technique that minimizes these errors. With these objective data processing techniques we have improved the reproducibility of the technique to +/- 10-15% error. This modified technique provides a promising new method for viewing and quantifying cartilage volume from standard diagnostic MR images.
我们的目标是开发一种准确且客观的技术，利用磁共振成像（MRI）和三维数据处理来描绘和定量关节软骨。
已开发出一种三维图像分析方法，该方法提供了一种从标准诊断性磁共振图像测量软骨体积的非侵入性技术。
使用计算机工作站，将快速场回波（FFE）磁共振图像中的软骨重建为三维（3D）图像。使用校准测试对象对现有计算机软件获得的厚度和体积测量的准确性及可重复性进行了测试。我们描述了在尝试使用现有计算机软件对软骨进行定量时遇到的误差来源、为减少这些误差而开发的方法，以及一项使用健康人类志愿者的初步软骨体积研究。
我们已识别出使用现有三维计算机软件进行软骨体积估计时所涉及的误差，并开发了一种数据处理技术，将这些误差降至最低。通过这些客观的数据处理技术，我们已将该技术的可重复性提高至误差在±10% - 15% 。这种改进后的技术为从标准诊断性磁共振图像观察和定量软骨体积提供了一种有前景的新方法。
