Kan K, Tase C, Ohto H, Isosu T, Niitsu K
Department of Anesthesiology, Fukushima Medical College.
Masui. 1995 Jan;44(1):92-5.
A normovolemic pulmonary edema associated with blood transfusion developed in a 38-year-old woman during gynecological operation. Bilateral pulmonary infiltrates and profound leucopenia (700.microliters-1) were observed. An antibody reactive with the recipient's neutrophils was found in a donor and an antibody reacting with the lymphocytes of the recipient was identified in another donor. Both donors were multiparous women. Respiratory failure was improved with mechanical ventilation but chest X-ray showed pulmonary infiltrates for the next 3 days. The white blood cell count rose to 2900.microliters-1 in the next day, and it took 2 weeks to be normalized. Transient pulmonary infiltrates can be caused by antileukocyte antibodies passively transfused by multiparous donors.
一名38岁女性在妇科手术期间发生了与输血相关的正常血容量性肺水肿。观察到双侧肺部浸润和严重白细胞减少（700/微升）。在一名供者中发现了与受者中性粒细胞反应的抗体，在另一名供者中鉴定出与受者淋巴细胞反应的抗体。两名供者均为经产妇。机械通气使呼吸衰竭得到改善，但胸部X光在接下来3天显示有肺部浸润。次日白细胞计数升至2900/微升，恢复正常需要2周时间。经产妇供者被动输注的抗白细胞抗体可导致短暂性肺部浸润。
