遗传因素决定血压对胰岛素抵抗和高胰岛素血症的反应：呼吁重新聚焦高血压的胰岛素假说。

Genetic factors determine the blood pressure response to insulin resistance and hyperinsulinemia: a call to refocus the insulin hypothesis of hypertension.

作者信息

Mark A L, Anderson E A

机构信息

Cardiovascular Center, University of Iowa, Iowa City.

出版信息

Proc Soc Exp Biol Med. 1995 Apr;208(4):330-6. doi: 10.3181/00379727-208-43862c.

DOI:10.3181/00379727-208-43862c

PMID:7700882

Abstract

We have briefly reviewed the controversy regarding the role of insulin resistance and hyperinsulinemia in the pathogenesis of hypertension in an attempt to emphasize the evidence in support of this concept. In so doing, we have highlighted the concept that genetic factors may determine sensitivity or resistance to the hypertensive effects of insulin resistance and hyperinsulinemia. We hope that this idea will help to reconcile seemingly conflicting evidence on this hypothesis and will focus future research.

摘要

我们简要回顾了关于胰岛素抵抗和高胰岛素血症在高血压发病机制中作用的争议，以强调支持这一概念的证据。在此过程中，我们强调了遗传因素可能决定对胰岛素抵抗和高胰岛素血症高血压作用的敏感性或抵抗性这一概念。我们希望这一观点将有助于调和关于这一假说看似相互矛盾的证据，并为未来的研究指明方向。