Barron S, Irvine J
Psychology Department, University of Kentucky, Lexington 40506.
Pharmacol Biochem Behav. 1995 Jan;50(1):107-14. doi: 10.1016/0091-3057(95)00303-e.
This study examined the effects of neonatal cocaine exposure on behavior using a rodent model. Rat pups were implanted with intragastric cannulas on postnatal day (PND) 4 and artificially reared (AR) from PND 4-10. The AR groups included two cocaine doses (20 mg/kg per day and 60 mg/kg per day) and an AR control. A sham surgery control group was also included that was reared naturally by its dam. Offspring from these neonatal treatment groups were examined for suckling performance (PND 13), passive avoidance learning (PND 23-24), activity (PND 18-21), or spontaneous alternation (PND 21). Neonatal cocaine exposure had no effect on suckling measures or passive avoidance learning. Activity was increased in the 60 mg/kg per day cocaine group relative to controls. In addition, spontaneous alternation was delayed in the 20 mg/kg per day cocaine-exposed females relative to all other groups. These data suggest that neonatal cocaine exposure may alter performance on some relatively simple tasks. More work is clearly warranted to look at the effects of neonatal cocaine exposure on more complex behaviors.
本研究使用啮齿动物模型，考察了新生期接触可卡因对行为的影响。在出生后第4天（PND4）给幼鼠植入胃内插管，并从PND4至PND10进行人工饲养（AR）。AR组包括两个可卡因剂量组（每天20mg/kg和每天60mg/kg）以及一个AR对照组。还包括一个假手术对照组，该组由母鼠自然抚养。对这些新生期治疗组的后代进行了哺乳性能（PND13）、被动回避学习（PND23 - 24）、活动能力（PND18 - 21）或自发交替行为（PND21）的检测。新生期接触可卡因对哺乳指标或被动回避学习没有影响。与对照组相比，每天60mg/kg可卡因组的活动能力增强。此外，与所有其他组相比，每天20mg/kg可卡因暴露组的雌性幼鼠自发交替行为延迟。这些数据表明，新生期接触可卡因可能会改变一些相对简单任务的表现。显然，有必要开展更多工作来研究新生期接触可卡因对更复杂行为的影响。
