Tomie A, Shultz P L, Spicer M S, Peoples L L
Department of Psychology (Busch Campus), Rutgers University, New Brunswick, NJ 08903.
Pharmacol Biochem Behav. 1995 Jan;50(1):115-9. doi: 10.1016/0091-3057(95)00304-f.
Procedures are reported that maintain control by the drug cue during and after drug discrimination training with lower doses that yield predominantly vehicle-appropriate choices. Twelve pigeons were trained to discriminate chlordiazepoxide (CDP) from saline using two-key (drug vs. vehicle) drug discrimination procedures. Intermixed within each block of 30 sessions were nine sessions of training with 8.0 mg/kg CDP, nine with one of seven lower training doses (4.0, 2.8, 2.0, 1.4, 1.0, 0.7, or 0.5 mg/kg CDP), and 12 with saline. The lower training dose was decreased across blocks. The three lowest training doses (1.0, 0.7, and 0.5 mg/kg CDP) yielded predominantly saline-appropriate choices but had no effect on discrimination of 8.0 mg/kg CDP or saline. Three doses (2.0, 1.4, and 1.0 mg/kg CDP) were retrained, and each yielded percentages of drug-appropriate choices nearly identical to those obtained during previous training. This drug discrimination procedure maintains control by the drug cue during and after training with vehicle-like doses of the training drug and may allow for repeated assessment of effects of low training doses.
据报道，在药物辨别训练期间及之后，使用较低剂量的药物线索来维持控制，这些较低剂量主要产生与赋形剂相符的选择。12只鸽子接受训练，使用双键（药物与赋形剂）药物辨别程序来区分氯氮卓（CDP）和生理盐水。在每30节训练课程的每个组块中，穿插进行9节使用8.0mg/kg CDP的训练课程、9节使用七种较低训练剂量之一（4.0、2.8、2.0、1.4、1.0、0.7或0.5mg/kg CDP）的训练课程以及12节使用生理盐水的训练课程。较低的训练剂量在各个组块中逐渐降低。三种最低的训练剂量（1.0、0.7和0.5mg/kg CDP）主要产生与生理盐水相符的选择，但对8.0mg/kg CDP或生理盐水的辨别没有影响。对三种剂量（2.0、1.4和1.0mg/kg CDP）进行了重新训练，每种剂量产生的与药物相符的选择百分比几乎与之前训练期间获得的百分比相同。这种药物辨别程序在使用类似赋形剂剂量的训练药物进行训练期间及之后，通过药物线索维持控制，并且可能允许对低训练剂量的效果进行重复评估。
