Johansson C, Jackson D M, Svensson L
Astra Arcus AB, Södertälje, Sweden.
Psychopharmacology (Berl). 1994 Dec;116(4):437-42. doi: 10.1007/BF02247475.
The effect of various typical (haloperidol) and atypical (clozapine, raclopride, remoxipride) antipsychotics on phencyclidine (PCP)-induced disruption of sensorimotor gating was tested in rats using an acoustic startle paradigm. Clozapine (4-40 mumol/kg), haloperidol (1-5 mumol/kg) and raclopride (1-12 mumol/kg) failed to reverse PCP-induced disruption of prepulse inhibition (PPI) of the acoustic startle response. In contrast, remoxipride (12-60 mumol/kg) caused a dose-dependent block of this effect. PCP-induced disruption of PPI is a widely accepted animal model of a corresponding behavioural deficit observed in schizophrenia although little evidence has been presented that it is in fact sensitive to antipsychotic agents. The present results indicate that remoxipride behaves in a unique way in this model compared to clozapine, haloperidol and raclopride.
采用听觉惊吓范式，在大鼠中测试了各种典型抗精神病药物（氟哌啶醇）和非典型抗精神病药物（氯氮平、雷氯必利、瑞莫必利）对苯环己哌啶（PCP）诱导的感觉运动门控破坏的影响。氯氮平（4 - 40 μmol/kg）、氟哌啶醇（1 - 5 μmol/kg）和雷氯必利（1 - 12 μmol/kg）未能逆转PCP诱导的听觉惊吓反应的前脉冲抑制（PPI）破坏。相比之下，瑞莫必利（12 - 60 μmol/kg）导致这种效应的剂量依赖性阻断。PCP诱导的PPI破坏是精神分裂症中观察到的相应行为缺陷的一种广泛接受的动物模型，尽管几乎没有证据表明它实际上对抗精神病药物敏感。目前的结果表明，与氯氮平、氟哌啶醇和雷氯必利相比，瑞莫必利在该模型中的表现独特。
