将CD4+ T细胞转移至C.B-17 SCID小鼠：一种在体内研究Th1和Th2细胞分化与调控的模型。 - Suppr

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超能文献

Transfer of CD4+ T cells to C.B-17 SCID mice: a model to study Th1 and Th2 cell differentiation and regulation in vivo.

作者信息

Powrie F, Coffman R L, Correa-Oliveira R

机构信息

DNAX Research Institute of Molecular and Cellular Biology Inc., Palo Alto, CA 94304, USA.

出版信息

Res Immunol. 1994 Jun;145(5):347-53. doi: 10.1016/s0923-2494(94)80198-3.

DOI:10.1016/s0923-2494(94)80198-3

PMID:7701113

Abstract

摘要

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Transfer of CD4+ T cells to C.B-17 SCID mice: a model to study Th1 and Th2 cell differentiation and regulation in vivo.将CD4+ T细胞转移至C.B-17 SCID小鼠：一种在体内研究Th1和Th2细胞分化与调控的模型。

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The use of the murine model of infection with Leishmania major to reveal the antagonistic effects that IL-4 can exert on T helper cell development and demonstrate that these opposite effects depend upon the nature of the cells targeted for IL-4 signaling.利用利什曼原虫主要亚种感染的小鼠模型来揭示白细胞介素-4（IL-4）对辅助性T细胞发育可能产生的拮抗作用，并证明这些相反的作用取决于IL-4信号传导所针对的细胞性质。

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The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells.利什曼原虫主要种感染后早期的白细胞介素-4反应以及由此导致的辅助性T细胞2型（Th2）细胞成熟，从而促使BALB/c小鼠发生进行性疾病，这一过程受调节性CD4+CD25+ T细胞的控制。

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