Hansen B E, Thorogood J, Hermans J, Ploeg R J, Van Bockel J H, Van Houwelingen J C
Department of Medical Statistics, Leiden University, The Netherlands.
Stat Med. 1994;13(23-24):2517-29. doi: 10.1002/sim.4780132314.
This paper concerns the survival analysis of liver transplant patients when patients with a potentially fatal rejection of the transplanted organ may receive a retransplant. A multistate model, analysing the states 'alive with first graft' and 'alive with second graft' separately, is suggested. Proportional hazards models and logistic regression models are used to evaluate which risk factors related to donor, preservation and recipient, influence the transition intensities. The complete model is used to predict overall survival of a patient and to study the influence of the risk factors on total survival.
本文关注肝移植患者的生存分析，此时移植器官出现潜在致命性排斥反应的患者可能接受再次移植。本文提出了一个多状态模型，分别分析“首次移植存活”和“二次移植存活”状态。使用比例风险模型和逻辑回归模型来评估与供体、保存和受体相关的哪些风险因素会影响转移强度。完整模型用于预测患者的总体生存情况，并研究风险因素对总生存的影响。
