Ysebaert D, Van Hee R, Hubens G, Vaneerdeweg W, Eyskens E
Dept. of Surgery, University Hospital Antwerp, Belgium.
Scand J Gastroenterol Suppl. 1994;207:42-4. doi: 10.3109/00365529409104194.
The efficacy of total parenteral nutrition and somatostatin was assessed in reducing output and promoting spontaneous closure of postoperative digestive fistulas.
In a consecutive series of 23 patients, closure was achieved in 83% of patients after a mean fistula duration of 11.0 +/- 7.9 days and a mean of 13.2 +/- 7.0 days of drug treatment, and without mortality.
A marked first-day effect (output drop > 50%) was noted in 60% of patients and had a good prognosis. Infection of the fistula markedly prolonged fistula closure time, but did not affect total outcome.
Somatostatin has been shown to be very useful in the conservative treatment of digestive fistulas because of its ability to reduce output significantly and to accelerate spontaneous closure.
评估了全胃肠外营养和生长抑素在减少术后消化瘘的排出量及促进其自发闭合方面的疗效。
在连续的23例患者系列中，瘘管平均持续时间为11.0±7.9天，平均药物治疗时间为13.2±7.0天，83%的患者实现了闭合，且无死亡病例。
60%的患者在第一天有显著效果（排出量下降>50%），且预后良好。瘘管感染显著延长了瘘管闭合时间，但不影响总体结果。
生长抑素已被证明在消化瘘的保守治疗中非常有用，因为它能够显著减少排出量并加速自发闭合。
