Ott P, Clemmesen J O, Larsen F S, Ring-Larsen H
Rikshospitalet, København, medicinsk afdeling A.
Ugeskr Laeger. 1995 Feb 13;157(7):881-5.
The study describes consumption of and poisoning by analgesic drugs in Denmark during the period 1979-1992. During this period, fatal poisonings from analgesics almost doubled to 200 deaths per year (40% of all drug related deaths in Denmark). The annual consumption of opioids increased at the beginning of the period, but during 1985-1992 it was relatively constant at 20 million defined daily doses (DDD) and associated with 600 hospital admissions and 150-170 deaths due to poisoning per year. Within the opioid group dextropropoxyphene consumption and poisonings decreased following a National Board of Health initiative in 1985-1987. As for the weak analgesics, consisting mainly of paracetamol or salicylates, the total consumption increased gradually and reached 145 million DDD in 1992, corresponding to 160 tablets per inhabitant per year. This consumption was associated with approximately 750 hospital admissions and 40 deaths due to poisoning. As judged from the mortality per dose the weak analgesics are 20-30 times safer than the opioids.
该研究描述了1979年至1992年期间丹麦镇痛药的消费情况及中毒情况。在此期间，镇痛药导致的致命中毒事件几乎增加了一倍，达到每年200例死亡（占丹麦所有与药物相关死亡的40%）。阿片类药物的年消费量在该时期开始时有所增加，但在1985年至1992年期间相对稳定在2000万限定日剂量（DDD），每年导致600例住院治疗以及150至170例中毒死亡。在阿片类药物组中，右丙氧芬的消费量和中毒事件在1985年至1987年国家卫生局采取举措后有所下降。至于主要由对乙酰氨基酚或水杨酸盐组成的弱效镇痛药，其总消费量逐渐增加，在1992年达到1.45亿DDD，相当于每人每年160片。这种消费量导致了约750例住院治疗以及40例中毒死亡。从每剂量的死亡率判断，弱效镇痛药比阿片类药物安全20至30倍。
