Prokhorov G G, Potapov V V, Ogneva N S, Zybina N N
Vestn Khir Im I I Grek. 1994 Jan-Feb;152(1-2):30-4.
A thorough investigation of 120 patients with obliterating atherosclerosis of lower extremities, treated conservatively at a hospital and observed for 5 years have shown that such a treatment was most effective in patients with the initial stages of the disease. The mechanisms of positive effects is based on the dilatation of the peripheral arteries and the resulting decrease of the peripheral resistance of the vessels, improved cardiac activity, activation of microcirculation and tissue respiration. An important result of the treatment is an increased rate of the oxygen consumption by the tissues in the ischemic zone. It determines the pathogenetic direction of the therapy which leads to a delayed progress of the disease in 20% of the patients and improves the patient's state in 57% of cases.
对120例下肢闭塞性动脉粥样硬化患者进行了全面调查，这些患者在一家医院接受了保守治疗并观察了5年，结果表明这种治疗方法对疾病初期的患者最为有效。积极作用的机制基于外周动脉的扩张以及由此导致的血管外周阻力降低、心脏活动改善、微循环和组织呼吸激活。治疗的一个重要结果是缺血区组织的耗氧率增加。这决定了治疗的发病机制方向，该治疗使20%的患者疾病进展延迟，57%的病例患者状态得到改善。
