Wagner A E, Dunlop C I, Wertz E M, Chapman P L, Baxter G M, Klopp L S
Department of Clinical Sciences, Colorado State University, Fort Collins 80523.
Vet Surg. 1995 Jan-Feb;24(1):78-85. doi: 10.1111/j.1532-950x.1995.tb01300.x.
Seven horses, which were part of an investigation of the effect of endotoxin administration on vascular reactivity, were anesthetized on two separate occasions for surgical excision of 4-cm sections of palmar digital artery and vein. On the first occasion, the horses were given an infusion of 1 L 0.9% NaCl solution intravenously (i.v.) just before induction of anesthesia (control); on the second occasion, the horses received an infusion of 1 L 0.9% NaCl containing Escherichia coli endotoxin, 0.1 microgram/kg (endotoxin). On both occasions, anesthesia was induced with xylazine, guaifenesin, and ketamine, and maintained with halothane in oxygen. Hemodynamic measurements were made with the horses under anesthesia immediately before beginning surgery (period 1), during skin incision (period 2), during dissection and excision of the vessels (period 3), during skin suturing (period 4), and after completion of surgery during bandaging (period 5). Hemoglobin concentration and mixed venous oxygen content were greater at all periods in horses that received endotoxin. Otherwise, there were no significant differences in hemodynamic parameters between control horses and horses administered endotoxin before beginning surgery (period 1). During surgery and bandaging, horses administered endotoxin had significantly higher heart rate (periods 3, 4, and 5), cardiac index (periods 3, 4, and 5), and oxygen delivery (periods 2, 3, 4, and 5) than did control horses, and mean arterial blood pressure (period 2) and systemic vascular resistance (periods 2, 3, 4, and 5) were less than in control horses. Compared with period 1, surgical stimulation in control horses was associated with increased mean arterial blood pressure and systemic vascular resistance (periods 2, 3, 4, and 5), but cardiac index and oxygen delivery were decreased (periods 3, 4, and 5).(ABSTRACT TRUNCATED AT 250 WORDS)
七匹马参与了一项关于内毒素给药对血管反应性影响的研究，在两个不同的时间点进行麻醉，以便手术切除4厘米长的掌指动脉和静脉段。第一次，在麻醉诱导前，给马静脉输注1升0.9%氯化钠溶液（对照组）；第二次，给马输注1升含大肠杆菌内毒素（0.1微克/千克）的0.9%氯化钠溶液（内毒素组）。在这两个时间点，均用赛拉嗪、愈创甘油醚和氯胺酮诱导麻醉，并用氟烷和氧气维持麻醉。在麻醉状态下，于手术开始前（第1阶段）、皮肤切开时（第2阶段）、血管分离和切除时（第3阶段）、皮肤缝合时（第4阶段）以及手术完成后包扎时（第5阶段）对马进行血流动力学测量。接受内毒素的马在所有阶段的血红蛋白浓度和混合静脉血氧含量均较高。否则，在手术开始前（第1阶段），对照组马和接受内毒素的马在血流动力学参数上无显著差异。在手术和包扎期间，接受内毒素的马的心率（第3、4和5阶段）、心脏指数（第3、4和5阶段）和氧输送量（第2、3、4和5阶段）显著高于对照组马，而平均动脉血压（第2阶段）和全身血管阻力（第2、3、4和5阶段）低于对照组马。与第1阶段相比，对照组马的手术刺激导致平均动脉血压和全身血管阻力增加（第2、3、4和5阶段），但心脏指数和氧输送量降低（第3、4和5阶段）。（摘要截短于250字）
