Kantsaliev A L, Kozyreva E A, Kushlinskiĭ N E, Rottenberg V I, Klimenkov A A, Vasil'ev A V
Vopr Onkol. 1994;40(1-3):40-6.
The levels of activity of cathepsin D were compared in neoplastic and normal gastric mucosa in 42 patients, aged 39-78, at different stages of the disease. A relationship was established between cathepsin D activity and main clinico-morphological characteristics of stomach tumor: cathepsin D activity was found to increase with decreasing differentiation and increasing depth of invasion and metastatic spreading of tumor tissue. Possible involvement of proteolytic enzymes and, in particular, an aspartyl proteinase--cathepsin D--in the mechanisms of invasion and metastatic spreading of neoplasms is discussed.
对42例年龄在39 - 78岁、处于疾病不同阶段的患者的肿瘤性胃黏膜和正常胃黏膜中的组织蛋白酶D活性水平进行了比较。确定了组织蛋白酶D活性与胃肿瘤主要临床形态学特征之间的关系：发现组织蛋白酶D活性随着肿瘤组织分化程度降低、浸润深度增加和转移扩散而升高。讨论了蛋白水解酶特别是天冬氨酸蛋白酶——组织蛋白酶D——可能参与肿瘤侵袭和转移扩散机制的情况。
