Owens D K, Harris R A, Scott P M, Nease R F
Department of Veterans Affairs Medical Center, Palo Alto, California, USA.
Ann Intern Med. 1995 May 1;122(9):641-52. doi: 10.7326/0003-4819-122-9-199505010-00001.
OBJECTIVE. To determine the cost-effectiveness of a policy to screen surgeons for human immunodeficiency virus (HIV) infection to prevent transmission of HIV to patients having invasive procedures.
Cost-effectiveness analysis.
A one-time national screening program would identify approximately 137 surgeons with HIV infection (range, 28 to 423 surgeons) and would prevent approximately 4.3 infections (range, 1.9 to 21.3 infections) in patients treated by infected surgeons and 0.9 infections (range, 0 to 12.9 infections) in sexual partners of infected surgeons at a direct cost of $8.1 million and an induced cost of approximately $44 million. It would result in expenditures of $458,000 per year of life saved (range, $147,000 to $687,000 per year of life saved), whereas an annual screening program would result in expenditures of approximately $1.1 million per year of life saved (range, $338,000 to $1,886,000 per year of life saved). If the prevalence of HIV infection in surgeons is estimated to be three times our base-case estimate (an increase from 0.1% to 0.3%), annual screening would result in expenditures of approximately $741,000 per year of life saved. If the probability of seroconversion after a patient is exposed to a contaminated instrument is increased to 5.0% from our base-case estimate of 0.29%, an annual screening program would still cost more than $228,000 per year of life saved.
Screening surgeons for HIV to prevent transmission of HIV to patients having invasive procedures requires expenditures per year of life saved that are considerably in excess of those of most accepted health interventions. Surveillance studies of patients treated by surgeons infected with HIV should be continued to confirm that transmission of HIV to patients having invasive procedures is rare.
目的。确定一项筛查外科医生是否感染人类免疫缺陷病毒(HIV)以防止HIV传播给接受侵入性操作患者的政策的成本效益。
成本效益分析。
一次性全国筛查计划将识别出约137名感染HIV的外科医生(范围为28至423名外科医生),并将预防受感染外科医生治疗的患者中约4.3例感染(范围为1.9至21.3例感染)以及受感染外科医生的性伴侣中约0.9例感染(范围为0至12.9例感染),直接成本为810万美元,诱导成本约为4400万美元。这将导致每挽救一年生命的支出为45.8万美元(范围为每挽救一年生命14.7万美元至68.7万美元),而年度筛查计划将导致每挽救一年生命的支出约为110万美元(范围为每挽救一年生命33.8万美元至188.6万美元)。如果估计外科医生中HIV感染率是我们基础病例估计值的三倍(从0.1%增至0.3%),年度筛查将导致每挽救一年生命的支出约为74.1万美元。如果患者接触受污染器械后血清转化的概率从我们基础病例估计的0.29%增至5.0%,年度筛查计划每挽救一年生命的成本仍将超过22.8万美元。
筛查外科医生是否感染HIV以防止HIV传播给接受侵入性操作的患者,每挽救一年生命所需的支出大大超过大多数公认的健康干预措施。应继续对受HIV感染的外科医生治疗的患者进行监测研究,以确认HIV传播给接受侵入性操作患者的情况很少见。