囊性纤维化中不成比例的头部生长迟缓。
Disproportionate head growth retardation in cystic fibrosis.
作者信息
Ghosal S, Taylor C J, Pickering M, McGaw J, Beckles-Willson N, Wales J K
机构信息
Department of Paediatrics, University of Sheffield.
出版信息
Arch Dis Child. 1995 Feb;72(2):150-2. doi: 10.1136/adc.72.2.150.
Monthly increments of length, weight gain, and head circumference were recorded from birth to 4 years of age in 52 children with cystic fibrosis. At birth the children showed stunting. Standard deviation (SD) scores at birth for height, weight, and head circumference were -1.24, -0.72, and -1.82 respectively. Over the first four years, length and weight SD scores showed a consistent improvement. However, there was very limited improvement in head circumference, which stabilised 1 SD below the mean from 1.5 years to 4 years. Our data suggest that head growth lags behind gain in height and weight in children with cystic fibrosis despite good nutritional management in early infancy. The data may also support the expression of cystic fibrosis transmembrane conductance regulator in choroid plexus and ependyma.
对52名囊性纤维化患儿从出生到4岁期间的身长月增长、体重增加和头围进行了记录。这些患儿出生时即有发育迟缓。出生时身高、体重和头围的标准差（SD）评分分别为-1.24、-0.72和-1.82。在头四年里，身长和体重的SD评分持续改善。然而，头围的改善非常有限，从1.5岁到4岁一直稳定在低于均值1个标准差的水平。我们的数据表明，尽管在婴儿早期进行了良好的营养管理，但囊性纤维化患儿的头部生长仍落后于身高和体重的增长。这些数据也可能支持囊性纤维化跨膜传导调节因子在脉络丛和室管膜中的表达。
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