三唑并[4,5-f]喹啉。第六部分。9-氨基烷基（芳基）-2-甲基-2H-[4,5-f]喹啉作为抗癌剂的合成与评价。体外筛选的初步结果。
Triazolo[4,5-f]quinolines. Part VI. Synthesis and evaluation of 9-aminoalkyl(aryl)-2-methyl-2H-[4,5-f]quinolines as anticancer agents. Preliminary results of in vitro screening.
作者信息
Sanna P, Sequi P A, Paglietti G
机构信息
Istituto di Chimica Farmaceutica e Tossicologica, Università di Sassari.
出版信息
Farmaco. 1995 Jan;50(1):47-54.
PMID:7702720
Abstract
9-Aminoalkyl(aryl)-2-methyl-2H-triazolo[4,5-f] quinolines were prepared in order to evaluate their in vitro antitumor activity. Some members of this series exhibited both cell selectivity and tumor growth inhibition activity at concentrations between 10(-8) and 10(-4)M. In particular, compounds Ia,c,m,o,p and q showed percent growth near zero at midpoint between 10(-5) and 10(-4)M in most cell lines.
摘要
制备9-氨基烷基（芳基）-2-甲基-2H-三唑并[4,5-f]喹啉以评估其体外抗肿瘤活性。该系列的一些成员在10^(-8)至10^(-4)M的浓度下表现出细胞选择性和肿瘤生长抑制活性。特别是，化合物Ia、c、m、o、p和q在大多数细胞系中，在10^(-5)至10^(-4)M的中点处生长百分比接近零。
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