Bertha C M, Hosmane S H, Zhang H, Hosmane N S
Department of Chemistry and Biochemistry, University of Maryland, Baltimore 21228.
J Biomol Struct Dyn. 1994 Oct;12(2):413-37. doi: 10.1080/07391102.1994.10508749.
The design, synthesis, structure, and properties of two tetrafunctional organic reagents, namely, 2,2'-sulfonylbis[3-(carboxymethylamino)-(E,E)-N-(2-chloroeth yl)propenamide] (SBCCP) (1) and 2,2'-sulfonylbis[3-(carboxymethylamino)-(E,E)-N-(2-oxoeth yl)propenamide] (SBCOP) (2) are reported. Reagents 1 and 2 contain reactive bis(alkyl halide) and bis(aldehyde) functions, respectively, as well as bis(carboxylic acid) moieties. The reagents have potential applications for biomacromolecular cross-linking, in particular for the cross-linking of hemoglobin subunits. Single-crystal X-ray diffraction data of synthetic intermediates (4,5, and 12) provided information about structural features and tether lengths of the target reagents.
报道了两种四官能有机试剂，即2,2'-磺酰基双3-(羧甲基氨基)-(E,E)-N-(2-氯乙基)丙烯酰胺(1)和2,2'-磺酰基双3-(羧甲基氨基)-(E,E)-N-(2-氧代乙基)丙烯酰胺(2)的设计、合成、结构及性质。试剂1和2分别含有反应性双(卤代烷基)和双(醛)官能团以及双(羧酸)部分。这些试剂在生物大分子交联方面有潜在应用，特别是用于血红蛋白亚基的交联。合成中间体(4、5和12)的单晶X射线衍射数据提供了有关目标试剂结构特征和连接长度的信息。
