Tranquilli A L, Mazzanti L, Staffolani R, Salvolini E, Garzetti G G, Romanini C
Institute of Gynecology and Obstetrics, University of Ancona.
Boll Soc Ital Biol Sper. 1994 Oct-Nov;70(10-11):249-56.
Platelet functionality alterations have been correlated to the onset of hypertension in pregnancy and oral Mg++ supplementation has been clinically postulated to counteract such alterations. We, therefore tested the effect of 4 weeks oral Mg++ pyrrolidone carboxylate supplementation on platelet function. Forty-eight pregnant women were enrolled in the study at the beginning of the third trimester (30-32 weeks). Twenty women were preeclamptic, while 28 remained normotensive and served as controls. All the women received 360 mg/day magnesium pyrrolidone carboxylate for 4 weeks. DPH fluorescence, Na+/K(+)-ATPase and Ca(++)-ATPase activity, intracellular free Ca++ concentrations were determined prior and after the 4-weeks supplementation. Oral Mg++ supplementation significantly increased platelet DPH fluorescence in both normotensive and preeclamptic women. In normotensive pregnant women, it also significantly increased the activity of Na+/K(+)-ATPase, the activity of Ca(++)-ATPase and reduced the concentration of intraplatelet free Ca++. In hypertensive pregnant women, Mg supplementation increases Na+/K(+)-ATPase activity and decreases intracellular free Ca++; this, in turn, contributes to reducing the activity of Ca(++)-ATPase. Magnesium supplementation to preventing hypertension in pregnancy seems to have a consistent biochemical and clinical background.
血小板功能改变与妊娠期高血压的发病有关，临床上推测口服镁离子补充剂可对抗这种改变。因此，我们测试了口服4周吡咯烷酮羧酸盐镁对血小板功能的影响。48名孕妇在孕晚期（30 - 32周）开始时被纳入研究。20名妇女患有先兆子痫，而28名血压正常作为对照。所有妇女每天接受360毫克吡咯烷酮羧酸盐镁，持续4周。在4周补充前后测定双苯甲酰甲烷（DPH）荧光、钠钾ATP酶和钙ATP酶活性、细胞内游离钙浓度。口服镁补充剂显著增加了血压正常和先兆子痫妇女的血小板DPH荧光。在血压正常的孕妇中，它还显著增加了钠钾ATP酶的活性、钙ATP酶的活性并降低了血小板内游离钙的浓度。在高血压孕妇中，补充镁增加了钠钾ATP酶的活性并降低了细胞内游离钙；这反过来又有助于降低钙ATP酶的活性。补充镁预防妊娠期高血压似乎有一致的生化和临床背景。
