环磷酰胺和高剂量类固醇在瘢痕性类天疱疮性眼病中的作用。
Role of cyclophosphamide and high dose steroid in ocular cicatricial pemphigoid.
作者信息
Elder M J, Lightman S, Dart J K
机构信息
Moorfields Eye Hospital, London.
出版信息
Br J Ophthalmol. 1995 Mar;79(3):264-6. doi: 10.1136/bjo.79.3.264.
AIMS/BACKGROUND: Ocular cicatricial pemphigoid (OCP) can present with severe conjunctival inflammation that requires systemic immunosuppression to avoid serious ocular morbidity. This study aimed to assess the clinical response to cyclophosphamide and short term, high dose prednisolone in this group of patients.
METHODS
A prospective, unmasked study assessed patients presenting with either 'severe' ocular inflammation (n = 4) or 'marked' or 'severe' ocular inflammation that had failed to respond to other systemic immunosuppression (n = 6). Nineteen inflamed eyes of 10 consecutive patients were enrolled.
RESULTS
The ocular inflammation resolved in 15 eyes in a mean time of 2.4 months. Two eyes perforated despite treatment and one patient was unable to tolerate the medication. Progressive cicatrisation occurred in 21%.
CONCLUSION
Cyclophosphamide and short term, high dose prednisolone are effective in severe inflammation caused by OCP but may not completely prevent cicatrisation.
目的/背景：眼部瘢痕性类天疱疮（OCP）可表现为严重的结膜炎症，需要全身免疫抑制以避免严重的眼部并发症。本研究旨在评估环磷酰胺和短期大剂量泼尼松龙对该组患者的临床疗效。
方法
一项前瞻性、非盲研究评估了出现“严重”眼部炎症的患者（n = 4）或对其他全身免疫抑制无反应的“显著”或“严重”眼部炎症患者（n = 6）。纳入了连续10例患者的19只发炎眼睛。
结果
15只眼睛的眼部炎症在平均2.4个月内消退。尽管进行了治疗，仍有2只眼睛穿孔，1例患者无法耐受该药物。21%的患者出现进行性瘢痕形成。
结论
环磷酰胺和短期大剂量泼尼松龙对OCP引起的严重炎症有效，但可能无法完全预防瘢痕形成。
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