Greenstreet E H, Djamgoz M B
Biology Department, Imperial College of Science, Technology and Medicine, London, UK.
Neuroreport. 1994 Dec 30;6(1):109-12. doi: 10.1097/00001756-199412300-00029.
This study tested the possible involvement of nitric oxide (NO) in light-adaptive morphological changes in the outer retina of a cyprinid fish, the roach. Isolated retinae were treated in the dark by either of two NO-donor compounds (S-nitroso-n-acetylpenicillamine and sodium nitroprusside) and then studied by light and electron microscopy; similar results were obtained in both cases. Application of NO induced contraction of cone photo-receptor myoids (i.e. retinomotor movements) and formation of horizontal cell spinules. Accordingly the cone index and the spinule/ribbon ratio showed 15-20% and 49-95% change, respectively, compared with controls. These results are consistent with involvement of NO in the light adaptation process in the outer retina of teleost fish.
